| Pair Name | Vitamin C, Cisplatin | ||
| Phytochemical Name | Vitamin C (PubChem CID: 54670067 ) | ||
| Anticancer drug Name | Cisplatin (PubChem CID: 5702198 ) | ||
| Structure of Phytochemical |
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2D
MOL
3D
MOL
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| Structure of Anticancer Drug |
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MOL
3D
MOL
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| Pair Name | Vitamin C, Cisplatin | |||
| Disease Info | [ICD-11: 2B51] | Osteosarcoma | Investigative | |
| Biological Phenomena | Induction-->Glycolysis | |||
| Gene Regulation | Up-regulation | Expression | ROS1 | hsa6098 |
| Up-regulation | Expression | H2AX | hsa3014 | |
| Up-regulation | Expression | HK2 | hsa3099 | |
| Up-regulation | Expression | SLC16A4 | hsa9122 | |
| Up-regulation | Expression | G6PD | hsa2539 | |
| Up-regulation | Expression | MYC | hsa4609 | |
| In Vitro Model | 143B | Osteosarcoma | Homo sapiens (Human) | CVCL_2270 |
| U2OS | Osteosarcoma | Homo sapiens (Human) | CVCL_0042 | |
| Result | Our findings provide a rationale for combining cisplatin with ascorbate in therapeutic strategies against OS. | |||
| No. | Title | Href |
|---|---|---|
| 1 | Ascorbate sensitizes human osteosarcoma cells to the cytostatic effects of cisplatin. Pharmacol Res Perspect. 2020 Aug;8(4):e00632. doi: 10.1002/prp2.632. | Click |
